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Olanzapine-[d8]

General Information
Catalog: BLP-008559
CAS: 1093380-13-2
Molecular Formula: C17H12D8N4S
Molecular Weight: 320.49
Chemical Structure
Olanzapine-[d8]
Description Olanzapine-[d8] is the isotope labelled analog of Olanzapine, which has been considered to be used for treating chizophrenia, bipolar disorder, and psychotic depression.
Synonyms 2-Methyl-4-(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)-10H-thieno[2,3-b][1,5]Benzodiazepine
IUPAC Name 2-methyl-4-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
Related CAS 132539-06-1 (unlabelled)
Canonical SMILES CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C
InChI InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3/i7D2,8D2,9D2,10D2
InChI Key KVWDHTXUZHCGIO-UFBJYANTSA-N
Purity 98% by CP; 98% atom D

Olanzapine-[d8], a deuterated variant of the antipsychotic Olanzapine, finds diverse applications in both research and clinical domains. Here are the key applications of Olanzapine-[d8]:

Pharmacokinetic Studies: Delving into the intricacies of drug metabolism and distribution, Olanzapine-[d8] is a pivotal tool in pharmacokinetic investigations. By leveraging this deuterated analogue, researchers can discern between the administered drug and its metabolites with heightened precision during mass spectrometry. This differentiation aids in unraveling the drug's absorption, distribution, metabolism, and excretion (ADME) characteristics, offering profound insights into its pharmacokinetic profile.

Drug Interaction Studies: As a stable-traceable marker in analyses of drug-drug interactions, Olanzapine-[d8] unveils its significance. Its distinctive isotopic signature empowers scientists to explore potential interactions with other medications sans the confounding influence of endogenous metabolites. This capability proves paramount in foreseeing adverse interactions and safeguarding patient well-being within complex polypharmacy contexts.

Analytical Method Development: In the laboratories of pharmaceutical establishments, Olanzapine-[d8] emerges as a cornerstone for analytical method development and validation, specifically for quantifying Olanzapine across diverse matrices. Acting as an internal standard, it elevates the precision and accuracy of chromatographic and spectrometric assays, thereby underpinning robust quality control standards during the production and dissemination of Olanzapine products.

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