Name: Olmesartan Medoxomil-[d4]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-013072

CAS: 1127298-55-8

Molecular Formula: C29H26D4N6O6

Molecular Weight: 562.61

Chemical Structure

Description	Olmesartan Medoxomil-[d4] is the labelled analogue of Olmesartan Medoxomil, which is a metabolite of Olmesartan. Olmesartan is a specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effect.
Synonyms	Olmesartan-d4 Medoxomil; 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid-d4 (5-Methyl-2-oxo-1,3-dioxol-4-yl]methyl Ester; Benicar-d4; Olmetec-d4
IUPAC Name	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[2,3,5,6-tetradeuterio-4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate
Related CAS	144689-63-4 (unlabelled)
Canonical SMILES	CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O
InChI	InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)/i11D,12D,13D,14D
InChI Key	UQGKUQLKSCSZGY-WQKXEYJYSA-N
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance	White Solid
Storage	Store at -20°C

Olmesartan Medoxomil-[d4], a stable isotope-labeled compound utilized primarily in research and analytical chemistry, boasts a plethora of applications. Here are the key applications:

Pharmacokinetic Studies: Delving into the realm of pharmacokinetics, Olmesartan Medoxomil-[d4] plays an integral role in deciphering the absorption, distribution, metabolism, and excretion (ADME) of Olmesartan Medoxomil within the body. By meticulously tracking the labeled compound, researchers can pinpoint the drug's half-life, bioavailability, and metabolic pathways with precision. This critical information underpins the optimization of dosages, ensuring therapeutic efficacy and safety are upheld to the highest standards.

Bioanalytical Assays: Within the realm of bioanalytical testing, Olmesartan Medoxomil-[d4] emerges as an indispensable internal standard for quantifying Olmesartan Medoxomil levels in biological samples employing cutting-edge techniques such as mass spectrometry. The isotope-labeled variant facilitates exact and meticulous measurement of drug concentration, proving invaluable in clinical trials and regulatory adherence. This application is paramount for validating assay methodologies, guaranteeing unwavering drug quality.

Drug Interaction Studies: Pioneering innovative research, scientists harness Olmesartan Medoxomil-[d4] to explore potential drug-drug interactions and their repercussions on Olmesartan Medoxomil's pharmacokinetics. By scrutinizing the impact of concurrent medications on Olmesartan's metabolism and efficacy, researchers can forecast adverse interactions, fortifying patient safety protocols. This critical application sheds light on intricate pharmacological interplays, steering the crafting of comprehensive therapeutic directives.

Metabolite Profiling: In the domain of metabolite profiling, Olmesartan Medoxomil-[d4] takes center stage in identifying and quantifying metabolites of Olmesartan Medoxomil across diverse biological matrices. The labeled compound acts as a beacon distinguishing parent drug molecules from their metabolites facilitating an exhaustive analysis of metabolic pathways. This profound insight is paramount in drug development, ensuring meticulous characterization of all metabolic byproducts to guarantee safety and efficacy are unequivocally established.