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Olodanrigan-[d7]

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General Information
Catalog: BLP-005290
Molecular Formula: C32H22D7NO5
Molecular Weight: 514.63

Chemical Structure

Description	Olodanrigan-[d7] is a deuterium labelled form of Olodanrigan. Olodanrigan (EMA401) is an orally bioavailable, potent and highly selective antagonist of the angiotensin II type 2 receptor (AT2; IC50s = 39.5 and 408,000 nM for rat recombinant AT2 and AT1, respectively). It inhibits capsaicin-induced calcium influx in cultured human dorsal root ganglion (hDRG) neurons (IC50 = 10 nM) and reduces neurite density and length in rat DRG neuronal cultures.
Synonyms	EMA401 D7
IUPAC Name	(3S)-5-[dideuterio-(2,3,4,5,6-pentadeuteriophenyl)methoxy]-2-(2,2-diphenylacetyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
Related CAS	1316755-16-4 (unlabelled)
Canonical SMILES	COC1=C(C2=C(CN(C(C2)C(=O)O)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)OCC5=CC=CC=C5
InChI	InChI=1S/C32H29NO5/c1-37-28-18-17-25-20-33(31(34)29(23-13-7-3-8-14-23)24-15-9-4-10-16-24)27(32(35)36)19-26(25)30(28)38-21-22-11-5-2-6-12-22/h2-18,27,29H,19-21H2,1H3,(H,35,36)/t27-/m0/s1/i2D,5D,6D,11D,12D,21D2
InChI Key	GHBCIXGRCZIPNQ-GFMVRNEQSA-N
Storage	Store at -20°C