Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-003672 |
Molecular Formula: C29H46D7NO5 |
Molecular Weight: 502.77 |
Chemical Structure |
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Description | Orlistat-[d7], is the labelled analogue of Orlistat, which is a pancreatic lipase inhibitor acting locally in the gastrointestinal tract to inhibit lipase. |
Synonyms | Orlistat D7 |
IUPAC Name | [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-4,5,5,5-tetradeuterio-2-formamido-4-(trideuteriomethyl)pentanoate |
Related CAS | 96829-58-2 (unlabelled) |
Canonical SMILES | CCCCCCCCCCCC(CC1C(C(=O)O1)CCCCCC)OC(=O)C(CC(C)C)NC=O |
InChI | InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1/i3D3,4D3,23D |
InChI Key | AHLBNYSZXLDEJQ-YHFVJDSMSA-N |
Purity | 97% by CP; 98% atom D |
Solubility | Soluble in Chloroform, Methanol |
Appearance | Off-white to Light Tan Solid |
Storage | Store at-20°C |
Orlistat-[d7], a deuterated variant of the anti-obesity drug Orlistat, is primarily utilized in research settings. Here are key applications of Orlistat-[d7] presented with high perplexity and burstiness:
Pharmacokinetic Studies: Orlistat-[d7] plays a pivotal role in pharmacokinetic investigations aimed at unraveling the absorption, distribution, metabolism, and excretion of Orlistat within the human body. Its deuterated structure enables precise tracking and discrimination from endogenous compounds, offering invaluable insights for optimizing dosing strategies and enhancing therapeutic efficacy.
Analytical Chemistry: Acting as an internal standard in mass spectrometry and various analytical techniques, Orlistat-[d7] ensures the accurate quantification of Orlistat levels in biological specimens. Serving as a stable reference, Orlistat-[d7] facilitates precise measurement of the parent drug, essential for developing robust assays for drug monitoring and ensuring stringent quality control in pharmaceutical formulations.
Drug Metabolism Research: Orlistat-[d7] serves as a key tool in elucidating the metabolic pathways of Orlistat, aiding researchers in identifying metabolites and comprehending the drug's biotransformation mechanisms. The insights gleaned from these studies contribute to predicting metabolic interactions and potential side effects, thereby informing the refinement of drug formulations and the mitigation of adverse reactions.
Toxicological Studies: Within the realm of toxicological research, Orlistat-[d7] plays a vital role in evaluating the safety profile and potential toxicities associated with Orlistat usage. By monitoring its fate and effects in preclinical models, researchers can pinpoint any detrimental metabolites or accumulations, supporting the development of safer therapeutic protocols and ensuring adherence to stringent regulatory standards.
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