Oseltamivir acid-[13C,d3] - Isotope / BOC Sciences

General Information
Catalog: BLP-003681
Molecular Formula: C13[13C]H21D3N2O4
Molecular Weight: 288.36

General Information

Catalog: BLP-003681

Molecular Formula: C13[13C]H21D3N2O4

Molecular Weight: 288.36

Chemical Structure

Description	Oseltamivir Acid-[13C,d3] is the labelled analogue of Oseltamivir Acid, which is a metabolite of Oseltamivir. Oseltamivir is an antiviral medication used to treat and prevent influenza A and influenza B.
Synonyms	Oseltamivir Acid-13C,D3; Oseltamivir-13C,d3 Acid; (3R,4R,5S)-4-Acetylamino-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic Acid-13C,d3; Oseltamivir-13C,d3 Carboxylic Acid; Oseltamivir Carboxylate-13C,d3; Oseltamivir EP Impurity C-13C,d3
IUPAC Name	(3R,4R,5S)-5-amino-3-pentan-3-yloxy-4-[(2,2,2-trideuterioacetyl-13C)amino]cyclohexene-1-carboxylic acid
Related CAS	187227-45-8 (unlabelled)
Canonical SMILES	CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)O
InChI	InChI=1S/C14H24N2O4/c1-4-10(5-2)20-12-7-9(14(18)19)6-11(15)13(12)16-8(3)17/h7,10-13H,4-6,15H2,1-3H3,(H,16,17)(H,18,19)/t11-,12+,13+/m0/s1/i3+1D3
InChI Key	NENPYTRHICXVCS-UHQFSAABSA-N
Purity	98% by HPLC; 98% atom D; 98% atom 13C
Solubility	Soluble in DMSO, Methanol
Appearance	White to Pale Brown Solid
Storage	Store at -20°C

Oseltamivir acid-[13C,d3], a specialized antiviral compound used in both research and clinical settings, serves various vital purposes. Here are the key applications of Oseltamivir acid-[13C,d3]:

Pharmacokinetic Studies: Delving into the complex processes of absorption, distribution, metabolism, and excretion within the body, researchers rely on Oseltamivir acid-[13C,d3] for pharmacokinetic studies. The isotopic labeling enables precise concentration measurements through mass spectrometry, shedding light on the drug's behavior and aiding in the optimization of dosing strategies. This meticulous analysis offers invaluable insights into the pharmacokinetics of oseltamivir, enhancing our understanding of its dynamics within the body.

Bioequivalence Testing: In the domain of generic antiviral drug development, Oseltamivir acid-[13C,d3] plays a critical role in bioequivalence testing. By comparing the pharmacokinetic profiles of generic drugs with the labeled compound, researchers ensure that the generic versions perform equivalently to branded drugs. This step is essential for regulatory approval and patient safety, guaranteeing the effectiveness and safety of generic alternatives through rigorous assessment of their performance.

Metabolic Pathway Analysis: Unraveling the intricate metabolic pathways involved in the biotransformation of oseltamivir requires the use of Oseltamivir acid-[13C,d3]. This labeled compound aids in the identification of metabolite structures and pathways through advanced analytical techniques, providing insights into drug efficacy and potential side effects. Understanding these pathways is crucial for optimizing the effectiveness and safety profiles of oseltamivir, guiding the development of more efficient and safer antiviral treatments.

Drug Interaction Studies: In the realm of drug-drug interaction assessments, Oseltamivir acid-[13C,d3] acts as a valuable tool for researchers. By serving as a marker in co-administration studies, this compound helps in investigating potential interactions between oseltamivir and other drugs. Monitoring how the presence of additional compounds influences oseltamivir's metabolism and activity provides critical insights into adverse interactions, ensuring the application of safe clinical practices. This data plays a pivotal role in anticipating and managing risks associated with drug interactions, contributing to enhanced patient safety and optimized treatment strategies.