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PD-0325901-[13C6]

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General Information
Catalog: BLP-001383
Molecular Formula: C10[13C]6H14F3IN2O4
Molecular Weight: 488.15

Chemical Structure

Description	A labelled compound of PD-0325901. PD-0325901 is a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.
Synonyms	N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide-13C6
Related CAS	391210-10-9 (unlabelled)
Purity	98%; 99% atom 13C
Appearance	White to beige solid