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Pemetrexed-[13C5,15N]

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Pemetrexed-[13C5,15N]

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General Information
Catalog: BLP-014066
Molecular Formula: C15[13C]5H21N4[15N]O6
Molecular Weight: 433.37

Chemical Structure

Description	Pemetrexed-[13C5,15N] is the labelled analogue of Pemetrexed. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.
Synonyms	Pemetrexed-13C5,15N; (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic-13C5-15N acid
Related CAS	137281-23-3 (unlabelled)
Solubility	Methanol (MeOH), Dimethylsulfoxide (DMSO)