Pentaglycine-[3,6,9,12,15,15-d6,O-d] - Isotope / BOC Sciences

General Information
Catalog: BLP-011541
Molecular Formula: C10H10D7N5O6
Molecular Weight: 310.32

General Information

Catalog: BLP-011541

Molecular Formula: C10H10D7N5O6

Molecular Weight: 310.32

Chemical Structure

Description	Pentaglycine-[3,6,9,12,15,15-d6,O-d] is the labelled analogue of Pentaglycine, which is an oligopeptide composed of 5 glycine molecules and could be a useful tumor necrosis factor receptor 2 agonist.
Synonyms	Pentaglycine-3,6,9,12,15,15-d6, O-d; Pentaglycine-d7; Gly-Gly-Gly-Gly-Gly-3,6,9,12,15,15-d6, O-d; Glycyl-glycyl-glycyl-glycyl-glycine-3,6,9,12,15,15-d6, O-d
IUPAC Name	deuterio 2-[deuterio-[2-[deuterio-[2-[deuterio-[2-[deuterio-[2-(dideuterioamino)acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetate
Related CAS	7093-67-6 (unlabelled)
Canonical SMILES	C(C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O)N
InChI	InChI=1S/C10H17N5O6/c11-1-6(16)12-2-7(17)13-3-8(18)14-4-9(19)15-5-10(20)21/h1-5,11H2,(H,12,16)(H,13,17)(H,14,18)(H,15,19)(H,20,21)/i/hD7
InChI Key	MXHCPCSDRGLRER-ZISDKLNRSA-N
Melting Point	−20°C
Purity	95% by HPLC; 97% atom D
Solubility	Soluble in Aqueous Acid (Slightly), Water (Slightly, Heated)
Appearance	Off-white Solid
Storage	Store at -20°C

Pentaglycine-[3,6,9,12,15,15-d6,O-d], a labeled peptide utilized in diverse scientific applications, plays a pivotal role in research and analytical environments. Here are key applications of Pentaglycine-[3,6,9,12,15,15-d6,O-d] presented with high perplexity and burstiness:

Mass Spectrometry: Serving as an internal standard in mass spectrometry, Pentaglycine-[3,6,9,12,15,15-d6,O-d] enables the precise quantification of peptides and proteins. Its stable isotope labeling ensures accurate measurements by compensating for matrix effects and instrumental variations. This application is indispensable in proteomics for conducting comparative analyses and discovering biomarkers.

Protein Structure Analysis: In the realm of protein chemistry, Pentaglycine-[3,6,9,12,15,15-d6,O-d] is a valuable tool for investigating protein folding and stability. The deuterium labeling provides intricate insights into hydrogen-deuterium exchange processes during protein interactions and conformational changes. This information is pivotal for understanding protein dynamics and designing stable biopharmaceuticals, pushing the boundaries of structural biology.

Peptide Synthesis: Functioning as a synthetic peptide, Pentaglycine-[3,6,9,12,15,15-d6,O-d] acts as a fundamental building block for constructing complex peptide chains. Researchers leverage its properties to explore the intricate processes of peptide bonding, assembly, and the effects of isotopic labeling on peptide characteristics. This knowledge is essential for advancing peptide-based therapeutics and molecular engineering, driving innovation in drug development.

Pharmacokinetics Studies: Deuterium-labeled compounds like Pentaglycine-[3,6,9,12,15,15-d6,O-d] play a critical role in pharmacokinetic studies by tracing metabolic pathways and elucidating the fate of peptides within biological systems. The isotopic labeling enables the differentiation between exogenous and endogenous peptides, offering crucial insights into absorption, distribution, metabolism, and excretion processes. This application facilitates the development of peptide drugs with enhanced efficacy and safety profiles, shaping the landscape of pharmaceutical research.