Name: Perindopril-[d5]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-003774

Molecular Formula: C19H27D5N2O5

Molecular Weight: 373.5

Chemical Structure

Description	Perindopril-[d5], is the labelled analogue of Perindopril. Perindopril is a long-acting ACE inhibitor. It is used to treat patients with hypertension, diabetes mellitus type 2, coronary heart disease, chronic heart failure or stable coronary artery disease in form of perindopril arginine on the basis of a large evidence.
Synonyms	Perindopril D5
IUPAC Name	(2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-oxo-1-(1,1,2,2,2-pentadeuterioethoxy)pentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Related CAS	82834-16-0 (unlabelled)
Canonical SMILES	CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O
InChI	InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1/i2D3,5D2
InChI Key	IPVQLZZIHOAWMC-QGLZVPSMSA-N
Purity	>98%
Storage	Store at-20°C

Perindopril-[d5], an isotopically labeled analogue of perindopril, an ACE inhibitor for cardiovascular conditions, serves as a cornerstone in various applications. Here are key applications illustrated with a high degree of perplexity and burstiness:

Pharmacokinetic Studies: Utilizing Perindopril-[d5] in pharmacokinetic investigations allows researchers to meticulously track the absorption, distribution, metabolism, and excretion pathways of perindopril within the body. By leveraging isotopically labeled compounds, scientists are able to precisely quantify perindopril levels in biological specimens. This crucial data aids in comprehending the behavior of the drug and fine-tuning dosing strategies for optimal therapeutic outcomes.

Drug Metabolism Research: Within the realm of drug metabolism research, Perindopril-[d5] acts as a powerful investigative tool, shedding light on the intricate metabolic pathways of perindopril. Researchers utilize this isotopically labeled compound to probe enzyme-catalyzed processes responsible for transforming the drug into its active metabolites. This insight not only helps in identifying potential drug interactions but also contributes to enhancing the safety and efficacy profile of perindopril in clinical practice.

Bioavailability Studies: The application of Perindopril-[d5] in bioavailability assessments provides a comprehensive understanding of how effectively perindopril is absorbed and circulated within the body. Through the monitoring of the isotope-labeled drug, scientists can ascertain the extent to which the drug reaches systemic circulation.

Analytical Method Development: In the domain of analytical method development, Perindopril-[d5] emerges as a quintessential reference and internal standard in mass spectrometry analyses. Its stable isotopic labeling enables accurate quantification even within complex matrices, facilitating precise analysis in both clinical settings and research laboratories. This contribution to reliable drug monitoring and quality control underscores the importance of Perindopril-[d5] in advancing pharmaceutical research and development.