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Permethrin-[d5]

General Information
Catalog: BLP-003777
CAS: 1794760-19-2
Molecular Formula: C21H15D5Cl2O3
Molecular Weight: 396.31
Chemical Structure
Permethrin-[d5]
Description Permethrin-[d5], is the labelled analogue of Permethrin. Permethrin is a synthetic pyrethroid insectide, affecting neuron membranes by prolonging sodium channel activation. It is used for the treatment of infestation with Sarcoptes scabiei (scabies).
Synonyms Permethrin D5
IUPAC Name [3-(2,3,4,5,6-pentadeuteriophenoxy)phenyl]methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate
Related CAS 52645-53-1 (unlabelled)
Canonical SMILES CC1(C(C1C(=O)OCC2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C
InChI InChI=1S/C21H20Cl2O3/c1-21(2)17(12-18(22)23)19(21)20(24)25-13-14-7-6-10-16(11-14)26-15-8-4-3-5-9-15/h3-12,17,19H,13H2,1-2H3/i3D,4D,5D,8D,9D
InChI Key RLLPVAHGXHCWKJ-YQYLVRRTSA-N
Boiling Point 465.9±45.0°C at 760 mmHg
Purity 95% by CP; 96% atom D
Density 1.3±0.1 g/cm3
Solubility Soluble in Chloroform, Ethyl Acetate, Methanol
Appearance White to Pale Yellow Sticky Solid to Solid
Storage Store at-20°C, Under inert atmosphere

Permethrin-[d5], a deuterated variant of the commonly used synthetic insecticide and acaricide permethrin, finds diverse applications in various fields portrayed with intricacy and variation:

Pesticide Research: Permethrin-[d5] serves as a fundamental element in groundbreaking research aimed at unraveling the complex mechanisms of insecticide resistance present in diverse insect populations. By leveraging its deuterated form, researchers embark on a precise journey to trace and quantify the metabolism of permethrin with unparalleled accuracy. This meticulous approach not only deepens our understanding of resistance pathways but also nurtures the evolution of cutting-edge pest management strategies, propelling the field forward with each innovative breakthrough.

Analytical Chemistry: Within the realm of analytical studies, Permethrin-[d5] plays an imperative role as an indispensable internal standard for quantifying permethrin residues across environmental and biological samples. The incorporation of deuterium atoms facilitates a clear differentiation between the deuterated and non-deuterated versions of permethrin during mass spectrometry analysis, ensuring meticulous and reliable measurement of pesticide concentrations within diverse matrices. This finely tuned analytical precision sets the stage for informed decision-making and accurate assessments in pesticide residue analysis.

Pharmacokinetics Studies: Permethrin-[d5] emerges as a crucial instrument in pharmacokinetic research, enabling in-depth exploration into the absorption, distribution, metabolism, and excretion dynamics of permethrin within organisms. By acting as a labeled compound, it allows researchers to precisely track the trajectory of permethrin within biological systems, shedding light on intricate metabolic pathways. These meticulous studies form the foundation for evaluating the safety and efficacy of permethrin across various applications, guiding the scientific community towards informed and responsible practices.

Ecotoxicology: In the domain of ecotoxicological evaluations, Permethrin-[d5] serves as a beacon of scientific inquiry, shedding light on the impact of permethrin on non-target organisms within ecosystems. Its specialized application enables scientists to closely monitor exposure levels and decipher the fate of permethrin in both aquatic and terrestrial environments. This critical information plays a pivotal role in safeguarding the responsible use of permethrin in pest control practices while simultaneously mitigating potential harm to wildlife populations. The meticulous assessment of permethrin's ecological footprint underscores the necessity for conscientious decision-making and sustainable environmental stewardship.

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