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Pimobendan-[d3]

General Information
Catalog: BLP-003818
Molecular Formula: C19H15D3N4O2
Molecular Weight: 337.38
Chemical Structure
Pimobendan-[d3]
Description Pimobendan-[d3], is the labelled analogue of Pimobendan, which is a veterinary medication. Pimobendan is both a calcium sensitizer and a selective inhibitor of phosphodiesterase III (PDE3) with positive inotropic and vasodilator effects.
Synonyms Pimobendan D3
IUPAC Name 6-(2-(4-(methoxy-d3)phenyl)-1H-benzo[d]imidazol-6-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
Related CAS 74150-27-9 (unlabelled)
Melting Point 166-169°C
Purity 98% by CP; 98% atom D
Solubility Soluble in DMSO, Methanol
Appearance White to Pale Yellow Solid
Storage Store at-20°C

Pimobendan-[d3], a deuterated derivative of Pimobendan, is a drug predominantly utilized in cardiology for managing heart-related conditions in animals. Here are the key applications of Pimobendan-[d3] presented with a high degree of perplexity and burstiness:

Cardiovascular Research: Delving into the realm of cardiovascular research, Pimobendan-[d3] assumes a pivotal role in investigating its impact on heart function and overall cardiovascular well-being. With its deuterated composition, this compound facilitates precise and sensitive pharmacokinetic assessments, enabling researchers to meticulously monitor its distribution and metabolic pathways within the body. Such intricate insights are paramount for fine-tuning dosage regimens and unraveling the therapeutic efficacy of the drug in addressing heart failure.

Veterinary Cardiology: Within the domain of veterinary cardiology, Pimobendan-[d3] is leveraged to enhance the management of heart failure in canine and feline patients. By boosting cardiac contractility and alleviating preload and afterload on the heart, it fosters overall cardiac function. Veterinarians prescribe this medication to prolong lifespan and enhance the quality of life in companion animals grappling with cardiac ailments such as dilated cardiomyopathy and chronic valvular heart disease.

Clinical Pharmacology: In the field of clinical pharmacology, Pimobendan-[d3] serves as a valuable tool for scrutinizing drug interactions and metabolic pathways. Its isotopic label facilitates in-depth exploration of how Pimobendan interacts with other medications during processing. This intricate analysis is vital for crafting safe and efficacious combination therapies, minimizing adverse interactions, and ensuring optimal therapeutic outcomes.

Pharmaceutical Development: The deuterated iteration of Pimobendan assumes a crucial role in pharmaceutical innovation, particularly in advancing cardiac therapies. By examining its stability and pharmacokinetic profile, researchers can formulate treatments with heightened efficacy and prolonged action duration.

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