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Plinabulin-[13C6]

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General Information
Catalog: BLP-001388
Molecular Formula: C13[13C]6H20N4O2
Molecular Weight: 342.34

Chemical Structure

Description	Labelled Plinabulin. Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 value of 9.8~18 nM in tumor cells under the development of Nereus Pharmaceuticals. It can bind to the colchicine binding site of b-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. In Sep 2016, BeyondSpring Pharmaceuticals planed a phase II/III trial for Neutropenia. Phase I clinical trials for Solid tumours and Phase III clinical trials for Non-small cell lung cancer are on-going.
Synonyms	(3Z,6Z)-3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)-2,5-Piperazinedione-13C6
Related CAS	714272-27-2 (unlabelled)
Purity	98%; 99% atom 13C
Appearance	Yellow to white powder