Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
---|
Catalog: BLP-013112 |
CAS: 1435933-86-0 |
Molecular Formula: C17H18D3ClN2S |
Molecular Weight: 323.90 |
Chemical Structure |
---|
![]() |
Description | An isotope labelled derivative of Promethazine. Promethazine is a neuroleptic medication. It has strong sedative and weak antipsychotic effects. It can be used as a sedative. |
Synonyms | N-methyl-1-phenothiazin-10-yl-N-(trideuteriomethyl)propan-2-amine;hydrochloride |
IUPAC Name | N-methyl-1-phenothiazin-10-yl-N-(trideuteriomethyl)propan-2-amine;hydrochloride |
Related CAS | 58-33-3 (unlabelled) |
Canonical SMILES | CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl |
InChI | InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H/i2D3; |
InChI Key | XXPDBLUZJRXNNZ-MUTAZJQDSA-N |
Purity | 98% |
Promethazine-[d3] HCl is a deuterated form of promethazine, primarily used in various research and pharmacological applications. Here are some key applications of Promethazine-[d3] HCl:
Pharmacokinetic Studies: Promethazine-[d3] HCl is utilized in pharmacokinetic studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of drugs. By using the deuterated form, researchers can differentiate between the administered drug and its endogenous counterparts. This aids in understanding the drug’s behavior in the body and optimizing dosage regimens.
Drug Metabolism Research: In drug metabolism studies, Promethazine-[d3] HCl serves as a tracer to explore metabolic pathways and enzyme interactions. It helps identify the enzymes involved in the biotransformation of promethazine and its metabolites. This information is vital for assessing drug interactions and potential side effects.
Analytical Chemistry: Promethazine-[d3] HCl is employed as an internal standard in mass spectrometry and other analytical chemistry techniques. The deuterated form provides a stable reference, improving the accuracy and precision of quantitative analyses. This is essential for ensuring reliable drug concentration measurements in biological samples.
Toxicology Studies: In toxicological research, Promethazine-[d3] HCl is used to study the safety profile and potential toxicity of promethazine. Researchers can monitor its distribution and effects in various tissues, aiding in the evaluation of toxicological risks. This is crucial for determining safe dosage levels and mitigating adverse effects.
Interested in our Service & Products?
Need detailed information?