CAS 1435933-86-0 Promethazine-[d3] HCl

General Information
Catalog: BLP-013112
CAS: 1435933-86-0
Molecular Formula: C17H18D3ClN2S
Molecular Weight: 323.90

General Information

Catalog: BLP-013112

CAS: 1435933-86-0

Molecular Formula: C17H18D3ClN2S

Molecular Weight: 323.90

Chemical Structure

Description	An isotope labelled derivative of Promethazine. Promethazine is a neuroleptic medication. It has strong sedative and weak antipsychotic effects. It can be used as a sedative.
Synonyms	N-methyl-1-phenothiazin-10-yl-N-(trideuteriomethyl)propan-2-amine;hydrochloride
IUPAC Name	N-methyl-1-phenothiazin-10-yl-N-(trideuteriomethyl)propan-2-amine;hydrochloride
Related CAS	58-33-3 (unlabelled)
Canonical SMILES	CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl
InChI	InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H/i2D3;
InChI Key	XXPDBLUZJRXNNZ-MUTAZJQDSA-N
Purity	98%

Promethazine-[d3] HCl is a deuterated form of promethazine, primarily used in various research and pharmacological applications. Here are some key applications of Promethazine-[d3] HCl:

Pharmacokinetic Studies: Promethazine-[d3] HCl is utilized in pharmacokinetic studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of drugs. By using the deuterated form, researchers can differentiate between the administered drug and its endogenous counterparts. This aids in understanding the drug’s behavior in the body and optimizing dosage regimens.

Drug Metabolism Research: In drug metabolism studies, Promethazine-[d3] HCl serves as a tracer to explore metabolic pathways and enzyme interactions. It helps identify the enzymes involved in the biotransformation of promethazine and its metabolites. This information is vital for assessing drug interactions and potential side effects.

Analytical Chemistry: Promethazine-[d3] HCl is employed as an internal standard in mass spectrometry and other analytical chemistry techniques. The deuterated form provides a stable reference, improving the accuracy and precision of quantitative analyses. This is essential for ensuring reliable drug concentration measurements in biological samples.

Toxicology Studies: In toxicological research, Promethazine-[d3] HCl is used to study the safety profile and potential toxicity of promethazine. Researchers can monitor its distribution and effects in various tissues, aiding in the evaluation of toxicological risks. This is crucial for determining safe dosage levels and mitigating adverse effects.