Propiomazine-[d6] hydrochloride - Isotope / BOC Sciences

General Information
Catalog: BLP-003907
Molecular Formula: C20H19D6ClN2OS
Molecular Weight: 382.98

General Information

Catalog: BLP-003907

Molecular Formula: C20H19D6ClN2OS

Molecular Weight: 382.98

Chemical Structure

Description	Propiomazine-[d6] hydrochloride, is the labelled analogue of Propiomazine. Propiomazine is an antihistamine blocking H1 receptors. It can be used for the treatment of insomnia, and to produce sleepiness or drowsiness and to relieve anxiety before or during surgery or other procedures and in combination with analgetics also during labor.
Synonyms	Propiomazine D6 hydrochloride
IUPAC Name	1-[10-[2-[bis(trideuteriomethyl)amino]propyl]phenothiazin-2-yl]propan-1-one;hydrochloride
Related CAS	1240-15-9 (unlabelled)
Canonical SMILES	CCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CC(C)N(C)C.Cl
InChI	InChI=1S/C20H24N2OS.ClH/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20;/h6-12,14H,5,13H2,1-4H3;1H/i3D3,4D3;
InChI Key	UGVNGSMLNPWNNA-SKCUOGQWSA-N
Solubility	Soluble in DMSO, Methanol
Storage	Store at-20°C

Propiomazine-[d6] hydrochloride is a stable isotope-labeled compound often used in pharmaceutical research and clinical studies. Here are some key applications of Propiomazine-[d6] hydrochloride:

Pharmacokinetic Studies: Propiomazine-[d6] hydrochloride is employed in pharmacokinetic studies to understand the absorption, distribution, metabolism, and excretion of propiomazine in the body. By using the labeled version, researchers can accurately track the drug's behavior and interactions in biological systems. This helps in optimizing dosing regimens and enhancing the safety and efficacy profiles of propiomazine-containing medications.

Metabolic Pathway Elucidation: In research studies, Propiomazine-[d6] hydrochloride is used to investigate metabolic pathways by tracking the compound's conversion into various metabolites. The deuterium label allows for the precise identification and quantification of metabolic products through advanced techniques such as mass spectrometry. This provides insights into how the body processes the medication and aids in detecting potential metabolic liabilities.

Drug Interaction Research: The labeled compound is valuable in studying drug-drug interactions, where researchers analyze how the presence of one drug influences the metabolism and pharmacokinetics of another. By using Propiomazine-[d6] hydrochloride, scientists can discern specific alterations in drug metabolism pathways, which is critical for predicting interaction effects.