CAS 1185247-12-4 Quetiapine-[d8] Fumarate

General Information
Catalog: BLP-003952
CAS: 1185247-12-4
Molecular Formula: C25H21D8N3O6S
Molecular Weight: 507.63

General Information

Catalog: BLP-003952

CAS: 1185247-12-4

Molecular Formula: C25H21D8N3O6S

Molecular Weight: 507.63

Chemical Structure

Description	Quetiapine-[d8] Fumarate, is the labelled analogue of Quetiapine. Quetiapine is an atypical antipsychotic medication used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.
Synonyms	Quetiapine-D8 Fumarate
IUPAC Name	2-[2-(4-benzo[b][1,4]benzothiazepin-6-yl-2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl)ethoxy]ethanol;(E)-but-2-enedioic acid
Related CAS	773058-82-5 (unlabelled)
Canonical SMILES	C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C(=CC(=O)O)C(=O)O
InChI	InChI=1S/C21H25N3O2S.C4H4O4/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;2-1+/i9D2,10D2,11D2,12D2;
InChI Key	VRHJBWUIWQOFLF-SMODUGIXSA-N
Melting Point	166-168°C
Purity	97% by CP; 98% atom D
Solubility	Soluble in DMSO, Methanol
Appearance	White Solid
Storage	Store at-20°C, Under inert atmosphere

Quetiapine-[d8] fumarate, a deuterated derivative of quetiapine, an antipsychotic medication, primarily utilized in pharmaceutical research. Delve into the diverse applications of Quetiapine-[d8] fumarate with a narrative brimming with perplexity and burstiness:

Pharmacokinetic Studies: Embark on a journey through the realm of clinical and preclinical pharmacokinetic studies, where the intricate absorption, distribution, metabolism, and excretion of quetiapine come to life. The deuterium labeling of Quetiapine-[d8] fumarate unlocks precise tracking capabilities within biological systems using cutting-edge mass spectrometry techniques. This invaluable information plays a pivotal role in fine-tuning dosing regimens and predicting potential drug interactions, shaping the future of pharmaceutical optimization.

Metabolite Identification: Step into the realm of pharmaceutical research, where Quetiapine-[d8] fumarate stands as a beacon for the identification and quantification of quetiapine metabolites. The distinct presence of deuterium acts as a guiding light, distinguishing the parent drug from its metabolites during meticulous analysis.

Drug Interaction Studies: Explore the dynamic landscape of drug interaction studies, where Quetiapine-[d8] fumarate plays a pivotal role in unraveling the intricate dance between quetiapine and other compounds. By harnessing the power of the deuterated version, researchers embark on a precise assessment of how co-administered drugs influence the metabolism and efficacy of quetiapine.

Reference Standard: Journey through the realm of analytical chemistry and quality control with Quetiapine-[d8] fumarate as your steadfast companion, a beacon of stability amidst the analytical storm. As a reference standard of unparalleled isotopic integrity, Quetiapine-[d8] fumarate serves as a cornerstone for the development and validation of analytical methods for quetiapine in both bulk and formulated pharmaceutical products.