Name: R-Doxazosin-[d8]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-004107

Molecular Formula: C23H17D8N5O5

Molecular Weight: 459.52

Chemical Structure

Description	R-Doxazosin-[d8] is a labelled isomer form of Doxazosin Mesylate. Doxazosin Mesylate is a selective α1-adrenoceptor antagonist.
Synonyms	2-{4-[(2R)-2,3-dihydro-1,4-benzodioxine-2-carbonyl](D8)piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine; (R)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-piperazine-d8
IUPAC Name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl]-[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methanone
Related CAS	70918-17-1 (unlabelled)
Canonical SMILES	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
InChI	InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26)/t20-/m1/s1/i7D2,8D2,9D2,10D2
InChI Key	RUZYUOTYCVRMRZ-PVLXMHINSA-N
Purity	>98%

R-Doxazosin-[d8], a deuterated variant of Doxazosin, serves as a potent alpha-blocker with diverse applications in both research and clinical environments. Delve into the multifaceted world of R-Doxazosin-[d8] with these following high-burstiness and perplexity narratives:

Pharmacokinetic Studies: Embark on a journey through the intricate realm of pharmacokinetics with R-Doxazosin-[d8]. This unique compound proves invaluable in unraveling the mysteries of drug absorption, distribution, metabolism, and excretion. The ingenious deuterium labeling strategy facilitates precise tracking in mass spectrometry, unraveling intricate details of the drug's behavior within the body. Such meticulous data is paramount for fine-tuning dosage regimens and comprehending the labyrinthine world of drug-drug interactions.

Hypertension Research: Peer into the depths of cardiovascular research with the enigmatic properties of R-Doxazosin-[d8]. As a stalwart alpha-adrenergic blocker, this compound takes center stage in unraveling its impact on blood pressure and vascular resistance. Researchers delve deep into the mechanisms underlying its role in managing hypertension, observing the dynamic shifts in blood vessel dilation and heart rate. These insights pave the way for the development of potent treatments for hypertension and its associated cardiovascular maladies.

BPH (Benign Prostatic Hyperplasia) Studies: Embark on a quest to decode the mysteries of benign prostatic hyperplasia with the aid of R-Doxazosin-[d8]. A prevalent ailment among the elderly, BPH comes under scrutiny as researchers investigate the compound's efficacy in alleviating urinary symptoms.

Analytical Chemistry: Dive into the realm of analytical chemistry with the potent tool that is R-Doxazosin-[d8]. Armed with stable isotope labeling, this compound emerges as a stalwart companion in the realm of quantitative analysis. Its role as an internal standardization tool proves pivotal in ensuring accurate assessments of Doxazosin levels in biological samples, compensating for the variability inherent in mass spectrometric evaluations. Such meticulous studies not only bolster the reliability of pharmacological data but also safeguard the precision of therapeutic monitoring protocols.