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Ribociclib-[d8]

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General Information
Catalog: BLP-004133
CAS: 2167898-24-8
Molecular Formula: C23H22D8N8O
Molecular Weight: 442.59

Chemical Structure

Description	Isotopic labelled Ribociclib, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
Synonyms	7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl-d8)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; LEE011-d8
Related CAS	1211441-98-3 (unlabelled)
Purity	98% atom D
Appearance	Beige Solid