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(S)-(+)-Camptothecin-[d5]

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General Information
Catalog: BLP-000735
CAS: 1329616-37-6
Molecular Formula: C20H11D5N2O4
Molecular Weight: 353.38

Chemical Structure

Description	(S)-(+)-Camptothecin-[d5] is the labelled analogue of Camptothecin. Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. Camptothecin is extratced from the barks of Camptotheca acuminata Decne. It can be used in cosmetics material.
Synonyms	(S)-(+)-Camptothecin D5; (S)-4-(Ethyl-d5)-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
IUPAC Name	(19S)-19-hydroxy-19-(1,1,2,2,2-pentadeuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
Related CAS	7689-03-4 (unlabelled)
Canonical SMILES	CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
InChI	InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1/i1D3,2D2
InChI Key	VSJKWCGYPAHWDS-CWDCNSFUSA-N
Purity	98%
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C