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(S)-Mesopram-[d7]

General Information
Catalog: BLP-000756
CAS: 1795786-04-7
Molecular Formula: C14H12D7NO4
Molecular Weight: 272.35
Chemical Structure
(S)-Mesopram-[d7]
Description (S)-Mesopram-[d7] is the labelled S-isomer of Mesopram. Mesopram is an orally active, selective phosphodiesterase (PDE) 4 inhibitor. In vitro, mesopram selectively inhibits the activity of type 1 helper T (Th1) cells without affecting cytokine production or proliferation of type 2 helper T (Th2) cells. It decreases the synthesis of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Some studies conclude that the specific type-4 phosphodiesterase inhibitor mesopram ameliorates murine colitis both in a preventive and a therapeutic setting.
Synonyms (S)-Mesopram D7; (5S)-5-[4-Methoxy-3-(propoxy-d7)phenyl]-5-methyl-2-oxazolidinone; (S)-5-[4-Methoxy-3-(propoxy-d7)phenyl]-5-methyl-2-oxazolidinone
IUPAC Name (5S)-5-[3-(1,1,2,2,3,3,3-heptadeuteriopropoxy)-4-methoxyphenyl]-5-methyl-1,3-oxazolidin-2-one
Related CAS 189940-24-7 (unlabelled free base)
Canonical SMILES CCCOC1=C(C=CC(=C1)C2(CNC(=O)O2)C)OC
InChI InChI=1S/C14H19NO4/c1-4-7-18-12-8-10(5-6-11(12)17-3)14(2)9-15-13(16)19-14/h5-6,8H,4,7,9H2,1-3H3,(H,15,16)/t14-/m1/s1/i1D3,4D2,7D2
InChI Key PCCPERGCFKIYIS-KMBCWLEASA-N

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