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Application Area
Environmental
Environmental

Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.

Clinical diagnostic
Clinical diagnostic

In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.

Organic Chemistry
Organic Chemistry

Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.

Metabolic Research
Metabolic Research

Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.

Sacubitril Calcium-[13C4]

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General Information
Catalog: BLP-004184
Molecular Formula: C20[13C]4H28NO5.1/2Ca
Molecular Weight: 434.50
Chemical Structure
Sacubitril Calcium-[13C4]
Description Labelled Sacubitril. Sacubitril, also known as AHU377 or LCZ696, is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.
Synonyms [S-(R*,S*)]-[1,1'-Biphenyl]-4-pentanoic Acid,γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-Ethyl Ester-13C4 Calcium
Related CAS 1369773-39-6 (unlabelled) 149709-62-6 (unlabelled free acid)
Canonical SMILES CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O.[Ca]
InChI InChI=1S/C24H29NO5.Ca/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/t17-,21+;/m1./s1/i13+1,14+1,22+1,23+1;
InChI Key SLERTBUHPREHKD-XIKWNFOHSA-N
Purity 99% by HPLC; 99% atom 13C
Appearance Off-white Solid
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