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Isotope Labeled Active Pharmaceutical Ingredients (APIs)
Sacubitril Calcium Salt-[d4]

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Sacubitril Calcium Salt-[d4]

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General Information
Catalog: BLP-004185
Molecular Formula: C24H24D4NO5(1/2Ca2+)
Molecular Weight: 434.52

Chemical Structure

Description	Labelled Sacubitril. Sacubitril, also known as AHU377 or LCZ696, is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.
Related CAS	1369773-39-6 (unlabelled)
Purity	≥98%
Solubility	Soluble in DMSO
Appearance	White to Off-white Powder
Storage	Store at 2-8°C