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Selumetinib-[13C6]

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General Information
Catalog: BLP-001400
Molecular Formula: C11[13C]6H15BrClFN4O3
Molecular Weight: 463.64

Chemical Structure

Description	Labelled Selumetinib. Selumetinib, also known as AZD6244, is an orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, and so may inhibit cellular proliferation in MEK-overexpressing tumor cells. MEK 1 and 2 are dual-specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various tumor cell types, and are drivers of diverse cellular activities, including cellular proliferation. Check for active clinical trials or closed clinical trials using this agent.
Related CAS	606143-52-6 (unlabelled)
Purity	98%; 99% atom 13C
Solubility	Soluble in Dimethyl sulfoxide (200 mg/mL) or Ethanol (2.5 mg/mL)
Appearance	White to Off-white solid