Name: Selurampanel-[13C,15N2,d3]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-004221

Molecular Formula: C15[13C]H16D3N3[15N]2O4S

Molecular Weight: 383.42

Chemical Structure

Description	Isotopic labelled Selurampanel, also known as BGG492, is a competitive AMPA/kainate receptor antagonist drug for epilepsy. As of 2015, is being investigated in clinical trials by Novartis for the treatment of epilepsy. It has also been studied in the acute treatment of migraine, and was found to produce some pain relief, but with a relatively high rate of side effects.
Synonyms	N-(7-isopropyl-6-(1-methyl-1H-pyrazol-5-yl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methanesulfonamide; [13C,2H3,15N2]-BGG492
IUPAC Name	1,1,1-trideuterio-N-[6-(2-methylpyrazol-3-yl)-2,4-dioxo-7-propan-2-yl-1H-quinazolin-3-yl](1-13C)methane(15N)sulfonamide
Related CAS	912574-69-7 (unlabelled)
Canonical SMILES	CC(C)C1=C(C=C2C(=C1)NC(=O)N(C2=O)NS(=O)(=O)C)C3=CC=NN3C
InChI	InChI=1S/C16H19N5O4S/c1-9(2)10-8-13-12(7-11(10)14-5-6-17-20(14)3)15(22)21(16(23)18-13)19-26(4,24)25/h5-9,19H,1-4H3,(H,18,23)/i4+1D3,19+1,21+1
InChI Key	MCECSFFXUPEPDB-TUYYILEKSA-N

Selurampanel-[13C,15N2,d3], an isotopically labeled derivative of the drug Selurampanel, finds primary utility in research environments. Here are key applications of Selurampanel-[13C,15N2,d3] presented with a high degree of perplexity and burstiness:

Pharmacokinetic Studies: The labeled Selurampanel is an indispensable tool in pharmacokinetic investigations, shedding light on the absorption, distribution, metabolism, and excretion (ADME) of the drug. Through the utilization of this isotopically enriched compound, researchers can meticulously trace the drug's journey through the body with enhanced precision, a critical aspect in fine-tuning dosing schedules and unraveling the drug's bioavailability intricacies.

Receptor Binding Studies: Renowned for its role as an AMPA receptor antagonist, Selurampanel serves as a gateway to studying the dynamics of receptor binding. The labeled variant empowers researchers to quantify binding affinities and kinetics, providing profound insights into the intricate dance between the drug and its target. This wealth of information is paramount in deciphering the mechanism of action and optimizing drug design strategies.

Neuroscience Research: Selurampanel-[13C,15N2,d3] emerges as a pivotal player in neuroscience exploration, offering a window into synaptic transmission and excitatory signaling pathways within the brain. By harnessing this compound, scientists can delve into the impact of AMPA receptors on neurological ailments like epilepsy and neuropathic pain, potentially paving the way for novel therapeutic modalities targeting these receptors.

Metabolomics: In the realm of metabolomics, isotopically labeled compounds such as Selurampanel-[13C,15N2,d3] serve as invaluable assets for identifying and quantifying metabolites in biological samples. This aids in unraveling the drug's metabolic fate and detecting any elusive metabolic intermediates. Such studies are indispensable for evaluating drug safety profiles and unearthing potential off-target effects, offering a comprehensive view of the drug's metabolic landscape.