Name: SMAD3 Inhibtor, SIS 3-[d3]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-004248

CAS: 1512629-88-7

Molecular Formula: C28H24D3N3O3

Molecular Weight: 456.55

Chemical Structure

Description	SMAD3 Inhibtor, SIS 3-[d3] is an isotope form of Smad3 Inhibitor, SIS3. SIS3 is an inhibitor of SMAD3, which is a receptor-regulated intracellular protein that functions downstream of TGF-β as well as activin receptors and mediates their signaling. It plays an important role in cell proliferation, apoptosis, differentiation and formation of extracellular matrix. It is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
Synonyms	1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-d3-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one; (2E)-1-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)-3-[1-(2H3)methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-propen-1-one
IUPAC Name	(E)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-[2-phenyl-1-(trideuteriomethyl)pyrrolo[2,3-b]pyridin-3-yl]prop-2-en-1-one
Related CAS	1009104-85-1 (unlabelled)
Canonical SMILES	CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5
InChI	InChI=1S/C28H27N3O3/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31/h4-12,14,16-17H,13,15,18H2,1-3H3/b12-11+/i1D3
InChI Key	IJYPHMXWKKKHGT-NTTJVEKVSA-N
Boiling Point	721.8±60.0°C at 760 mmHg
Density	1.2±0.1 g/cm3
Storage	Store at-20°C