Inquiry List

* Name:
* Phone:
* Service & Products of Interested: [Labelled Inhibitors] SMAD3 Inhibtor, SIS 3-[d3] (1512629-88-7)
Project Description:
* Quantity
* Email:
* Organization We recommend you to leave us your work email address so that we can serve you better. Please leave your organization information here if you don't have a work email address.
* Verification Code:

Our Highlights

Optimal Prices
Buying products on this site guarantees the best price
Flexible Batches
Flexible batch size to meet different needs of global customers
Prompt Delivery
Warehouses in multiple cities to ensure timely delivery
Quality Assurance
Strict process parameter control to ensure product quality
One-to-one Customization
One-to-one custom synthesis for special structural needs

Application Area

Environmental

Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.

Clinical diagnostic

In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.

Organic Chemistry

Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.

Metabolic Research

Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.

SMAD3 Inhibtor, SIS 3-[d3]

Inquiry

General Information
Catalog: BLP-004248
CAS: 1512629-88-7
Molecular Formula: C28H24D3N3O3
Molecular Weight: 456.55

Chemical Structure

Description	SMAD3 Inhibtor, SIS 3-[d3] is an isotope form of Smad3 Inhibitor, SIS3. SIS3 is an inhibitor of SMAD3, which is a receptor-regulated intracellular protein that functions downstream of TGF-β as well as activin receptors and mediates their signaling. It plays an important role in cell proliferation, apoptosis, differentiation and formation of extracellular matrix. It is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
Synonyms	1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-d3-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one; (2E)-1-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)-3-[1-(2H3)methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-propen-1-one
IUPAC Name	(E)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-[2-phenyl-1-(trideuteriomethyl)pyrrolo[2,3-b]pyridin-3-yl]prop-2-en-1-one
Related CAS	1009104-85-1 (unlabelled)
Canonical SMILES	CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5
InChI	InChI=1S/C28H27N3O3/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31/h4-12,14,16-17H,13,15,18H2,1-3H3/b12-11+/i1D3
InChI Key	IJYPHMXWKKKHGT-NTTJVEKVSA-N
Boiling Point	721.8±60.0°C at 760 mmHg
Density	1.2±0.1 g/cm3
Storage	Store at-20°C