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SN 38-[13C6]

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General Information
Catalog: BLP-001404
CAS: 718612-55-6
Molecular Formula: C16[13C]6H20N2O5
Molecular Weight: 398.36

Chemical Structure

Description	Labelled analogue of 7-Ethyl-10-hydroxycamptothecin. SN-38 is the active metabolite of irinotecan. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2-to 2000-fold. SN38 is metabolized via glucoronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of irinotecan predicts irinotecan toxicity, as it cannot be excreted from the body in its SN-38 form. SN-38 is lost into the bile and feces. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan. 7-Ethyl-10-hydroxycamptothecin is a natural compound found in the barks of Camptotheca acuminata Decne, it can be used in cosmetics material.
Synonyms	7-Ethyl-10-hydroxycamptothecin-13C6
Related CAS	86639-52-3 (unlabelled)
Purity	95%; 99% atom 13C
Appearance	Beige to brown solid