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Solifenacin-[d5]

General Information
Catalog: BLP-012688
CAS: 1401416-00-9
Molecular Formula: C23H21D5N2O2
Molecular Weight: 367.5
Chemical Structure
Solifenacin-[d5]
Description Solifenacin-[d5] is the labelled analogue of Solifenacin. Solifenacin is a drug used to treat contraction of overactive bladder.
Synonyms Solifenacin D5
IUPAC Name [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-(2,3,4,5,6-pentadeuteriophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate
Related CAS 242478-37-1 (unlabelled)
Canonical SMILES C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5
InChI InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1/i1D,2D,3D,7D,8D
InChI Key FBOUYBDGKBSUES-GNVVIGMASA-N
Boiling Point 505.5±50.0 °C at 760 mmHg
Purity 95% by HPLC; 98% atom D
Density 1.2±0.1 g/cm3

Solifenacin-[d5], a stable isotope-labeled analog of solifenacin, finds primary utility in research and clinical domains. Here are the key applications of Solifenacin-[d5]:

Pharmacokinetic Studies: Integral to pharmacokinetic investigations, Solifenacin-[d5] plays a pivotal role in unraveling the drug's absorption, distribution, metabolism, and excretion (ADME) within the body. By leveraging this labeled compound, researchers adeptly trace and quantify the drug in biological samples through advanced mass spectrometry techniques. This precise analysis fosters a deeper comprehension of the drug's dynamic behavior, facilitating the fine-tuning of dosing regimens for optimal patient outcomes.

Bioanalytical Testing: Within the realm of bioanalytical laboratories, Solifenacin-[d5] assumes a critical role as an internal standard for quantifying solifenacin levels in biological matrices. Its incorporation ensures heightened accuracy and precision in liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays. This meticulous approach is essential for therapeutic drug monitoring, underpinning the delivery of consistent and effective patient care.

Metabolic Pathway Elucidation: Researchers harness the potential of Solifenacin-[d5] to delve into the intricate metabolic pathways and breakdown products of solifenacin within biological systems. Through the adept tracking of the labeled analog, scientists pinpoint and characterize the metabolites generated in diverse tissues and fluids. Such detailed insights are indispensable for critically evaluating the safety and efficacy profiles of the drug, guiding informed decisions in clinical practice.

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