Tafamidis-[13C6]

General Information
Catalog: BLP-001407
Molecular Formula: C8[13C]6H7Cl2NO3
Molecular Weight: 314.07
Chemical Structure
Tafamidis-[13C6]
Description Tafamidis-[13C6] is a labelled version of Tafamidis. Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. It is a drug for the amelioration of transthyretin-related hereditary amyloidosis. It functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein and binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR.
Synonyms [13C6]-FX-1006A; [13C6]-2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
IUPAC Name 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
Related CAS 594839-88-0 (unlabelled)
Canonical SMILES C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
InChI InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)/i1+1,2+1,5+1,7+1,11+1,12+1
InChI Key TXEIIPDJKFWEEC-APZJDHTOSA-N
Purity 98%; 99% atom 13C

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