|Molecular Formula: C18[13C]H10D4F2N6O|
|Molecular Weight: 385.37|
|Description||Labelled analogue of Talazoparib. Talazoparib, also known as BMN-673, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development.|
|Related CAS||1207456-01-6 (unlabelled)|
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