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Talazoparib-[13C,d4]

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Talazoparib-[13C,d4]

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General Information
Catalog: BLP-004523
Molecular Formula: C18[13C]H10D4F2N6O
Molecular Weight: 385.37

Chemical Structure

Description	Labelled analogue of Talazoparib. Talazoparib, also known as BMN-673, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development.
Synonyms	(11S,12R)-7-fluoro-11-[4-fluoro(D4)phenyl]-12-(1-methyl-1H-1,2,4-triazol-5-yl)(11-13C)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one
IUPAC Name	(11S,12R)-7-fluoro-12-(2-methyl-1,2,4-triazol-3-yl)-11-(2,3,5,6-tetradeuterio-4-fluorophenyl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one
Related CAS	1207456-01-6 (unlabelled)
Canonical SMILES	CN1C(=NC=N1)C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F
InChI	InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1/i2D,3D,4D,5D,16+1
InChI Key	HWGQMRYQVZSGDQ-UWQIOMAISA-N
Purity	>98%

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