Name: TCEP-[d12] Hydrochloride
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-004557

CAS: 1189959-10-1

Molecular Formula: C9H4D12ClO6P

Molecular Weight: 298.72

Chemical Structure

Description	TCEP-[d12] Hydrochloride is an isotope analogue of TCEP Hydrochloride. TCEP Hydrochloride is used for selective reduction of disulfide bridges at low pH.
Synonyms	3,3',3''-Phosphinidynetrispropanoic Acid-d12; Tris(2-carboxyethyl)phosphine-d12 Hydrochloride; Tris(carboxyethyl)phosphine-d12 Hydrochloride
IUPAC Name	3-bis(2-carboxy-1,1,2,2-tetradeuterioethyl)phosphanyl-2,2,3,3-tetradeuteriopropanoic acid;hydrochloride
Related CAS	51805-45-9 (unlabelled)
Canonical SMILES	C(CP(CCC(=O)O)CCC(=O)O)C(=O)O.Cl
InChI	InChI=1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H/i1D2,2D2,3D2,4D2,5D2,6D2;
InChI Key	PBVAJRFEEOIAGW-XDVLEJMRSA-N
Melting Point	168-171°C
Solubility	Soluble in Methanol, Water
Appearance	White Solid
Storage	Store at -20°C, Under Inert Atmosphere

TCEP-[d12] Hydrochloride, a deuterated variant of the renowned reducing agent TCEP, finds frequent use in various biochemical applications. Below we delve into key applications of TCEP-[d12] Hydrochloride, described with a high degree of perplexity and burstiness:

Protein Structure Analysis: Embracing its role in mass spectrometry, TCEP-[d12] Hydrochloride emerges as a valuable tool for deciphering protein structures. Its ability to cleave disulfide bonds within proteins unveils crucial insights into their intricate three-dimensional architectures. This aids researchers in unraveling the enigmatic realms of protein folding and function, pivotal in the realm of innovative drug design.

Labeling in NMR Studies: Within the realm of nuclear magnetic resonance (NMR) spectroscopy, TCEP-[d12] Hydrochloride dons the mantle of a potent reducing agent, facilitating the maintenance of protein samples in a pristine reduced state. Its deuterated essence enhances the lucidity and precision of signals in spectral analyses, a boon for the meticulous study of protein dynamics and atomic-level interactions, unfurling the secrets of molecular choreography.

Sample Preparation in Proteomics: For proteomics aficionados, TCEP-[d12] Hydrochloride stands as a stalwart companion during sample preparation, ensuring proteins are primed in their reduced and denatured states. It efficiently cleaves disulfide bonds sans side chain labeling, preserving the native amino acid sequence in all its unadulterated glory for meticulous analysis. This preparatory ritual assumes a pivotal role in bolstering downstream applications like mass spectrometry and Western blotting, ensuring the fidelity of analytical outcomes.

Chemical Synthesis: Venturing into the domains of organic and organometallic chemistry, TCEP-[d12] Hydrochloride reveals its prowess as a discerning reducing agent. Its adeptness in reducing metal complexes and organic compounds lends credence to its value in the synthesis of intricate molecules. This precision becomes indispensable in the realm of pharmaceuticals, where the efficacy of reduction reactions holds the key to birthing active ingredients that can potentially transform therapeutic landscapes.