Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
General Information |
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Catalog: BLP-006018 |
Molecular Formula: C36H49D4N7O6 |
Molecular Weight: 683.87 |
Chemical Structure |
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Catalog Number | Size | Price | Stock | Quantity |
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BLP-006018 | 50 mg | $299 | In stock |
Description | Labelled Telaprevir. VX-950 is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). VX-950 forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(i)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of VX-950 and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with VX-950, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, VX-950 exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, VX-950 showed excellent inhibition of HCV NS3-4A protease activity in the liver. |
Synonyms | (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-[(cyclopropyl-d4)amino]-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide; LY 570310-d4; MP 424-d4; VRT 111950-d4; VX 950-d4 |
IUPAC Name | (3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1,2-dioxo-1-[(2,2,3,3-tetradeuteriocyclopropyl)amino]hexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide |
Related CAS | 402957-28-2 (unlabelled) |
Canonical SMILES | O=C(N[C@@H](C1CCCCC1)C(N[C@@H](C(C)(C)C)C(N2[C@H](C(N[C@H](C(C(NC3C([2H])([2H])C3([2H])[2H])=O)=O)CCC)=O)[C@](CCC4)([H])[C@]4([H])C2)=O)=O)C5=NC=CN=C5 |
InChI | InChI=1S/C36H53N7O6/c1-5-10-25(29(44)34(48)39-23-15-16-23)40-33(47)28-24-14-9-13-22(24)20-43(28)35(49)30(36(2,3)4)42-32(46)27(21-11-7-6-8-12-21)41-31(45)26-19-37-17-18-38-26/h17-19,21-25,27-28,30H,5-16,20H2,1-4H3,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t22-,24-,25-,27-,28-,30+/m0/s1/i15D2,16D2 |
InChI Key | BBAWEDCPNXPBQM-WSZQYWDLSA-N |
Melting Point | 116-123°C |
Purity | >98% |
Solubility | Soluble in Chloroform, Methanol (Slightly) |
Appearance | Pale Yellow to Light Yellow Waxy Solid |
Storage | Store at-20°C Freezer, Under Inert Atmosphere |
Quality Standard | - |
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