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Tenofovir Alafenamide-[d5] Fumarate (diastereomers)

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Tenofovir Alafenamide-[d5] Fumarate (diastereomers)

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General Information
Catalog: BLP-004580
Molecular Formula: C25H28D5N6O9P
Molecular Weight: 481.50

Chemical Structure

Description	A labelled form of Tenofovir alafenamide fumarate. Tenofovir alafenamide fumarate, also known as Tenofovir alafenamide hemifumarate. TAF, GS-7340, is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. It is under development by Gilead Sciences for use in the treatment of HIV infection. Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (Viread), Tenofovir alafenamide has greater antiviral activity and better distribution into lymphoid tissues than that agent. Gilead has announced a phase 3 clinical trial evaluating a single-tablet regimen combining GS-7340 with cobicistat, emtricitabine and elvitegravir and plans to coformulate the drug with cobicistat, emtricitabine and the protease inhibitor darunavir.
Synonyms	GS 7171-d5 Fumarate; 1-Methylethyl Ester N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine-d5 Fumarate
Related CAS	379270-38-9 (unlabelled)
Melting Point	104-107°C (dec.)
Purity	≥90%
Solubility	Soluble in DMSO, Methanol
Appearance	White to Off-white Solid
Storage	Hygroscopic, Store at -20°C, Under inert atmosphere

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