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TH-302-[d8]

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General Information
Catalog: BLP-004616
CAS: 918632-75-4
Molecular Formula: C9H8D8Br2N5O4P
Molecular Weight: 457.09

Chemical Structure

Description	Labelled TH-302. TH-302, also known as Evofosfamide, is a hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity.
Synonyms	N,N'-Bis(2-bromoethyl)phosphorodiamidic Acid-d8 (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl Ester
Related CAS	918633-87-1 (unlabelled)