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Toceranib-[d8]

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General Information
Catalog: BLP-007465
CAS: 1795134-78-9
Molecular Formula: C22H17D8FN4O2
Molecular Weight: 404.51

Chemical Structure

Description	Labelled compound of Toceranib. Toceranib is a potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively), which inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo.
Synonyms	5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl-d8)ethyl]-1H-pyrrole-3-carboxamide; 5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid (2-(Pyrrolidin-1-yl-d8)ethyl)amide
Related CAS	356068-94-5 (unlabelled)
Solubility	Soluble in Chloroform, Dichloromethane, DMSO