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Tolfenamic Acid-[d4]

General Information
Catalog: BLP-012815
CAS: 1246820-82-5
Molecular Formula: C14H3D4ClNO2
Molecular Weight: 265.73
Chemical Structure
Tolfenamic Acid-[d4]
Description Tolfenamic Acid-[d4] is the labelled analogue of Tolfenamic Acid, which is a non-steroidal anti-inflammatory drug (NSAID). It is a derivative of anthranilic acid, related structurally to Mefenamic and Flufenamic acids.
Synonyms Tolfenamic Acid D4; 2-[(3-Chloro-2-methylphenyl)amino]benzoic Acid-d4; N-(3-Chloro-o-tolyl)anthranilic Acid-d4; Clotam-d4; Migea-d4; N-(2-Methyl-3-chlorophenyl)anthranilic Acid-d4; Tolfedine-d4; Tolfine-d4
IUPAC Name 2-(3-chloro-2-methylanilino)-3,4,5,6-tetradeuteriobenzoic acid
Related CAS 13710-19-5 (unlabelled)
Canonical SMILES CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O
InChI InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)/i2D,3D,5D,7D
InChI Key YEZNLOUZAIOMLT-IKMBEDGYSA-N
Melting Point 209-212°C
Purity 98% by HPLC; 99% atom D
Solubility Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance Pale Purple Solid
Storage Store at 2-8°C

Tolfenamic Acid-[d4], the deuterated counterpart of Tolfenamic Acid, stands as a critical reference standard and analytical tool across diverse research fields. Here are the key applications of Tolfenamic Acid-[d4]:

Pharmacokinetic Studies: Immerse yourself in the intricate realm of pharmacokinetics, leveraging Tolfenamic Acid-[d4] as a key player in tracing the absorption, distribution, metabolism, and excretion (ADME) of Tolfenamic Acid within biological matrices. Utilizing this deuterated derivative as an internal standard in mass spectrometry empowers researchers to uncover precise and reliable data, shedding light on the nuanced behaviors of the drug in the body. Such insights are foundational in the realms of dosage form development and therapeutic monitoring, shaping the future of pharmaceutical sciences.

Metabolomic Research: Embark on a profound journey into metabolomics with the stable isotope-labeled Tolfenamic Acid-[d4] acting as a guiding light for quantifying Tolfenamic Acid and its metabolites across diverse biological samples. This steadfast companion ensures the accuracy and precision of measurements by harmonizing sample preparation intricacies and analytical fluctuations. Such meticulous analyses unravel the metabolic pathways and biological impacts of Tolfenamic Acid, painting a vivid portrait of biochemical interactions in living systems.

Environmental Analysis: Venture into the environmental frontiers with Tolfenamic Acid-[d4] as your beacon, illuminating the presence and consequences of Tolfenamic Acid in ecosystems. By introducing environmental samples to this deuterated compound, researchers can meticulously trace the path of Tolfenamic Acid through soils, waters, and biological realms. This vigilance fosters a deep understanding of environmental persistence and ecological implications, nurturing a sustainable coexistence with our natural surroundings.

Therapeutic Drug Monitoring: Enter the realm of clinical vigilance with Tolfenamic Acid-[d4] as a cornerstone in therapeutic drug monitoring, ensuring patient well-being and treatment efficacy. Serving as a calibration standard in assays aimed at quantifying Tolfenamic Acid concentrations in patient specimens, this deuterated ally plays a pivotal role in optimizing dosing regimens and mitigating adverse effects. Ultimately, it shapes improved patient outcomes and elevates clinical care standards.

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