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Tosedostat-[d5]

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General Information
Catalog: BLP-007478
CAS: 1217844-03-5
Molecular Formula: C21H25D5N2O6
Molecular Weight: 411.5

Chemical Structure

Description	Labelled Tosedostat. Tosedostat is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively, and does not effectively inhibit either PILSAP, MetAP-2, LTA4 hydrolase, or MetAP-2 with IC50 values are > 1000, > 5000, > 10000 and > 30000 nM for aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2 respectively. Phase 2. Tosedostat potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo.
Synonyms	(αS)-α-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]benzeneacetic Acid-d5 Cyclopentyl Ester; CHR 2797-d5
IUPAC Name	cyclopentyl 2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-2-(2,3,4,5,6-pentadeuteriophenyl)acetate
Related CAS	238750-77-1 (unlabelled)
Canonical SMILES	CC(C)CC(C(C(=O)NO)O)C(=O)NC(C1=CC=CC=C1)C(=O)OC2CCCC2
InChI	InChI=1S/C21H30N2O6/c1-13(2)12-16(18(24)20(26)23-28)19(25)22-17(14-8-4-3-5-9-14)21(27)29-15-10-6-7-11-15/h3-5,8-9,13,15-18,24,28H,6-7,10-12H2,1-2H3,(H,22,25)(H,23,26)/t16-,17?,18+/m1/s1/i3D,4D,5D,8D,9D
InChI Key	FWFGIHPGRQZWIW-XDBPGOACSA-N