Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
General Information |
---|
Catalog: BLP-001419 |
Molecular Formula: C20[13C]6H23FIN5O4 |
Molecular Weight: 621.35 |
Chemical Structure |
---|
![]() |
Description | Trametinib-[13C6] is a labelled version of Trametinib which is an anti-cancer drug. This a reversible inhibitor of mitogen-activated extracellular signal-regulated kinase (MEK1 and MEK2). Trametinib had good results for metastatic melanoma carrying the BRAF V600E mutation. Stable isotope labeled Trametinib is intended for use as an internal standard for the quantification of Trametinib by LC or GC-mass spectrometry. |
Synonyms | N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl-1,2,3,4,5,6-13C6)acetamide; Trametinib-13C6; CS-EK-01958 |
IUPAC Name | N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl](1,2,3,4,5,6-13C6)cyclohexa-1,3,5-trien-1-yl]acetamide |
Related CAS | 871700-17-3 (unlabelled) |
Canonical SMILES | CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5 |
InChI | InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)/i4+1,5+1,6+1,12+1,16+1,18+1 |
InChI Key | LIRYPHYGHXZJBZ-YGELHQHLSA-N |
Purity | >98%; 99% atom 13C |
Solubility | Soluble in Methanol or DMSO |
Appearance | Off-white solid |
Interested in our Service & Products?
Need detailed information?