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Trametinib-[13C6]

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General Information
Catalog: BLP-001419
Molecular Formula: C20[13C]6H23FIN5O4
Molecular Weight: 621.35

Chemical Structure

Description	Trametinib-[13C6] is a labelled version of Trametinib which is an anti-cancer drug. This a reversible inhibitor of mitogen-activated extracellular signal-regulated kinase (MEK1 and MEK2). Trametinib had good results for metastatic melanoma carrying the BRAF V600E mutation. Stable isotope labeled Trametinib is intended for use as an internal standard for the quantification of Trametinib by LC or GC-mass spectrometry.
Synonyms	N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl-1,2,3,4,5,6-13C6)acetamide; Trametinib-13C6; CS-EK-01958
IUPAC Name	N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl](1,2,3,4,5,6-13C6)cyclohexa-1,3,5-trien-1-yl]acetamide
Related CAS	871700-17-3 (unlabelled)
Canonical SMILES	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5
InChI	InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)/i4+1,5+1,6+1,12+1,16+1,18+1
InChI Key	LIRYPHYGHXZJBZ-YGELHQHLSA-N
Purity	>98%; 99% atom 13C
Solubility	Soluble in Methanol or DMSO
Appearance	Off-white solid