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Treosulfan-[d4]

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General Information
Catalog: BLP-007499
Molecular Formula: C6H10D4O8S2
Molecular Weight: 282.30

Chemical Structure

Description	Labelled Treosulfan. Treosulfan is the prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhbits myeloablative and immunosuppressive activities.
IUPAC Name	[(2S,3S)-1,1,4,4-tetradeuterio-2,3-dihydroxy-4-methylsulfonyloxybutyl] methanesulfonate
Related CAS	299-75-2 (unlabelled)
Canonical SMILES	CS(=O)(=O)OCC(C(COS(=O)(=O)C)O)O
InChI	InChI=1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1/i3D2,4D2
InChI Key	YCPOZVAOBBQLRI-OGDJEXPBSA-N
Solubility	Soluble in DMSO, Chloroform
Appearance	White to Off-white Solid
Storage	Store at 2-8°C