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Triciribine-[13C,d3]

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General Information
Catalog: BLP-007511
Molecular Formula: C12[13C]H13D3N6O4
Molecular Weight: 324.32

Chemical Structure

Description	Labelled Triciribine. Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme.
Synonyms	(2S,3S,4R,5S)-2-[5-amino-7-(13C,D3)methyl-2,6,7,9,11-pentaazatricyclo[6.3.1.04,12]dodeca-1(12),3,5,8,10-pentaen-2-yl]-5-(hydroxymethyl)oxolane-3,4-diol
IUPAC Name	(2R,3R,4S,5R)-2-[5-amino-7-(trideuterio(1-13C)methyl)-2,6,7,9,11-pentazatricyclo[6.3.1.04,12]dodeca-1(12),3,5,8,10-pentaen-2-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Related CAS	35943-35-2 (unlabelled)
Canonical SMILES	CN1C2=NC=NC3=C2C(=CN3C4C(C(C(O4)CO)O)O)C(=N1)N
InChI	InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1/i1+1D3
InChI Key	HOGVTUZUJGHKPL-DCFSSBKKSA-N
Purity	>98%