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Application Area
Environmental
Environmental

Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.

Clinical diagnostic
Clinical diagnostic

In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.

Organic Chemistry
Organic Chemistry

Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.

Metabolic Research
Metabolic Research

Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.

Triciribine-[13C,d3]

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General Information
Catalog: BLP-007511
Molecular Formula: C12[13C]H13D3N6O4
Molecular Weight: 324.32
Chemical Structure
Triciribine-[13C,d3]
Description Labelled Triciribine. Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme.
Synonyms (2S,3S,4R,5S)-2-[5-amino-7-(13C,D3)methyl-2,6,7,9,11-pentaazatricyclo[6.3.1.04,12]dodeca-1(12),3,5,8,10-pentaen-2-yl]-5-(hydroxymethyl)oxolane-3,4-diol
IUPAC Name (2R,3R,4S,5R)-2-[5-amino-7-(trideuterio(1-13C)methyl)-2,6,7,9,11-pentazatricyclo[6.3.1.04,12]dodeca-1(12),3,5,8,10-pentaen-2-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Related CAS 35943-35-2 (unlabelled)
Canonical SMILES CN1C2=NC=NC3=C2C(=CN3C4C(C(C(O4)CO)O)O)C(=N1)N
InChI InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1/i1+1D3
InChI Key HOGVTUZUJGHKPL-DCFSSBKKSA-N
Purity >98%
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