Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
General Information |
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Catalog: BLP-007511 |
Molecular Formula: C12[13C]H13D3N6O4 |
Molecular Weight: 324.32 |
Chemical Structure |
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Description | Labelled Triciribine. Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. |
Synonyms | (2S,3S,4R,5S)-2-[5-amino-7-(13C,D3)methyl-2,6,7,9,11-pentaazatricyclo[6.3.1.04,12]dodeca-1(12),3,5,8,10-pentaen-2-yl]-5-(hydroxymethyl)oxolane-3,4-diol |
IUPAC Name | (2R,3R,4S,5R)-2-[5-amino-7-(trideuterio(1-13C)methyl)-2,6,7,9,11-pentazatricyclo[6.3.1.04,12]dodeca-1(12),3,5,8,10-pentaen-2-yl]-5-(hydroxymethyl)oxolane-3,4-diol |
Related CAS | 35943-35-2 (unlabelled) |
Canonical SMILES | CN1C2=NC=NC3=C2C(=CN3C4C(C(C(O4)CO)O)O)C(=N1)N |
InChI | InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1/i1+1D3 |
InChI Key | HOGVTUZUJGHKPL-DCFSSBKKSA-N |
Purity | >98% |
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