CAS 1189923-38-3 Trimethoprim-[d3] - Isotope / BOC Sciences

General Information
Catalog: BLP-012640
CAS: 1189923-38-3
Molecular Formula: C14H15D3N4O3
Molecular Weight: 293.34

General Information

Catalog: BLP-012640

CAS: 1189923-38-3

Molecular Formula: C14H15D3N4O3

Molecular Weight: 293.34

Chemical Structure

Catalog Number	Size	Price	Stock	Quantity
BLP-012640	10 mg	$1099	In stock

Catalog Number

Size

Price

Stock

Quantity

BLP-012640

10 mg

$1099

In stock

Description	Trimethoprim-[d3] is the labelled analogue of Trimethoprim. Trimethoprim is an antibiotic used in the treatment of bladder infections.
Synonyms	Trimethoprim D3; [2H3]-Trimethoprime
IUPAC Name	5-[[3,5-dimethoxy-4-(trideuteriomethoxy)phenyl]methyl]pyrimidine-2,4-diamine
Related CAS	738-70-5 (unlabelled)
Isomeric SMILES	[2H]C([2H])([2H])OC1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC
Canonical SMILES	COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
InChI	InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)/i3D3
InChI Key	IEDVJHCEMCRBQM-HPRDVNIFSA-N
Boiling Point	526.0±60.0 °C at 760 mmHg
Melting Point	198-200°C
Purity	98% by HPLC; 98% atom D
Density	1.3±0.1 g/cm3
Solubility	Soluble in DMSO, Methanol
Appearance	White to Pale Yellow Solid
Storage	Store at -20°C, under inert atmosphere

Trimethoprim-[d3], a deuterium-labeled version of trimethoprim, is widely utilized in scientific research, boasting diverse applications. Here are the key applications:

Pharmacokinetic Studies: An indispensable tool in pharmacokinetic research, Trimethoprim-[d3] enables rigorous tracking of the absorption, distribution, metabolism, and excretion (ADME) processes of trimethoprim within the body. The deuterium labeling facilitates precise discrimination between the administered compound and endogenous substances, yielding invaluable insights into the drug's behavior in vivo. This data not only informs dosing regimens but also enhances our understanding of safety profiles and drug interactions.

Drug Interaction Research: Delving into the realm of drug interactions, researchers harness Trimethoprim-[d3] to scrutinize how other drugs impact the metabolism of trimethoprim. Leveraging the labeled drug simplifies the identification and isolation of trimethoprim and its metabolites, shedding light on potential adverse effects and the optimization of combination therapies. This nuanced approach to drug research underscores the importance of tailored treatment strategies for improved patient outcomes.

Environmental Monitoring: Emerging as a versatile tracer in environmental investigations, Trimethoprim-[d3] aids in monitoring the presence and degradation of trimethoprim in diverse ecosystems. Through meticulous differentiation between labeled and unlabeled forms, scientists can explore the persistence, dispersion, and breakdown of this compound in soil, water, and other environmental niches. This methodological approach enhances our ability to evaluate the environmental impact of pharmaceutical residues, highlighting the need for sustainable environmental stewardship.

Quantitative Mass Spectrometry: In the domain of analytical chemistry, Trimethoprim-[d3] assumes a pivotal role as an internal standard for quantitative mass spectrometric analysis. The consistent chemical characteristics of the labeled compound ensure precise quantification of trimethoprim in various biological matrices, underpinning clinical pharmacology, toxicology studies, and quality control in pharmaceutical production. This application underscores the significance of meticulous analytical tools in advancing our understanding of pharmacological phenomena and drug efficacy.