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Application Area
Environmental
Environmental

Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.

Clinical diagnostic
Clinical diagnostic

In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.

Organic Chemistry
Organic Chemistry

Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.

Metabolic Research
Metabolic Research

Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.

Trofosfamide-[d4]

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General Information
Catalog: BLP-007545
CAS: 1189884-36-3
Molecular Formula: C9H14D4Cl3N2O2P
Molecular Weight: 327.61
Chemical Structure
Trofosfamide-[d4]
Description Labelled Trofosfamide. Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and tumor cell apoptosis.
Synonyms N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-d4 2-Oxide; Ixoten-d4; NSC 109723-d4; Trifosfamide-d4; Trilofosfamida-d4; Trilophosphamide-d4; Triphosphamide-d4; Trisfosfamide-d4
IUPAC Name N,N,3-tris(2-chloroethyl)-4,4,5,5-tetradeuterio-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
Related CAS 22089-22-1 (unlabelled)
Isomeric SMILES [2H]C1(COP(=O)(N(C1([2H])[2H])CCCl)N(CCCl)CCCl)[2H]
Canonical SMILES C1CN(P(=O)(OC1)N(CCCl)CCCl)CCCl
InChI InChI=1S/C9H18Cl3N2O2P/c10-2-6-13-5-1-9-16-17(13,15)14(7-3-11)8-4-12/h1-9H2/i1D2,5D2
InChI Key UMKFEPPTGMDVMI-QEOHIWEKSA-N
Boiling Point 393.7±52.0°C at 760 mmHg
Melting Point 52-53°C
Density 1.4±0.1 g/cm3
Solubility Soluble in Chloroform, Methanol
Appearance White Solid
Storage Store at -20°C, Under Inert Atmosphere
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