Name: Verapamil-[d7]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-007592

CAS: 100578-79-8

Molecular Formula: C27H31D7N2O4

Molecular Weight: 461.64

Chemical Structure

Description	A labelled analogue of Verapamil. Verapamil is used for preventing angina pectoris attacks, arterial hypertension, and treating and preventing supraventricular arrhythmia (paroxysmal supraventricular tachycardia, atrial fibrillation, atrial flutter, extrasystole).
Synonyms	2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-[(1,1,1,2,3,3,3-D7)propan-2-yl]pentanenitrile
IUPAC Name	2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-(1,1,1,2,3,3,3-heptadeuteriopropan-2-yl)pentanenitrile
Related CAS	52-53-9 (unlabelled)
Canonical SMILES	CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
InChI	InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3/i1D3,2D3,20D
InChI Key	SGTNSNPWRIOYBX-ZGBMZCDDSA-N
Purity	>98%

Verapamil-[d7] is a deuterated form of verapamil, a calcium channel blocker used in cardiovascular research and treatment. Here are some key applications of Verapamil-[d7]:

Pharmacokinetic Studies: Verapamil-[d7] is used in pharmacokinetic studies to understand the absorption, distribution, metabolism, and excretion of verapamil in the body. The deuterium labeling allows for precise tracking and differentiation in mass spectrometry analyses. This helps in determining accurate dosing and understanding drug interactions.

Cardiovascular Research: In cardiovascular research, Verapamil-[d7] serves as a stable isotope-labeled standard to study the effects of verapamil on heart cells and tissues. It aids in elucidating the mechanisms by which verapamil impacts cardiac function and blood pressure. This research is vital for improving therapeutic strategies for conditions like hypertension and arrhythmias.

Drug Metabolism Studies: Verapamil-[d7] is used to investigate how verapamil is metabolized by enzymes in the liver and other tissues. By observing the metabolism process using deuterated verapamil, researchers can identify active metabolites and enzyme pathways involved. This information is crucial for predicting drug efficacy and potential side effects.

Analytical Chemistry: In analytical chemistry, Verapamil-[d7] is employed as an internal standard for the quantification of verapamil in biological samples. The use of a deuterated standard enhances the precision and reliability of mass spectrometric assays.