Name: Verinurad-[d6]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-007595

CAS: 1877347-77-7

Molecular Formula: C20H10D6N2O2S

Molecular Weight: 354.46

Chemical Structure

Description	Verinurad-[d6] is a labelled compound of Verinurad. Verinurad, a URAT1 inhibitor, has been found to have potential activity against gout and hyperuricaemia and is currently under Phase II trail. IC50: 0.05 μM (EC50).
Synonyms	2-[[3-(4-Cyano-1-naphthalenyl)-4-pyridinyl]thio]-2-(methyl-d3)propanoic-3,3,3-d3 acid
IUPAC Name	2-[3-(4-cyanonaphthalen-1-yl)pyridin-4-yl]sulfanyl-3,3,3-trideuterio-2-(trideuteriomethyl)propanoic acid
Related CAS	1352792-74-5 (unlabelled)
Canonical SMILES	CC(C)(C(=O)O)SC1=C(C=NC=C1)C2=CC=C(C3=CC=CC=C32)C#N
InChI	InChI=1S/C20H16N2O2S/c1-20(2,19(23)24)25-18-9-10-22-12-17(18)16-8-7-13(11-21)14-5-3-4-6-15(14)16/h3-10,12H,1-2H3,(H,23,24)/i1D3,2D3
InChI Key	YYBOLPLTQDKXPM-WFGJKAKNSA-N
Purity	>98%

Verinurad-[d6], a deuterated iteration of the renowned gout medication Verinurad, is meticulously crafted to drive down serum uric acid levels. Let's explore the multifaceted applications of Verinurad-[d6] with an elevated degree of perplexity and burstiness:

Pharmacokinetic Studies: Journey into the intricate realm of pharmacokinetic studies, where Verinurad-[d6] assumes a crucial role in unraveling the complex processes of drug absorption, distribution, metabolism, and excretion. The deuterated formulation offers a unique vantage point for precise tracking and differentiation from the unlabeled compound in biological samples, yielding invaluable insights to refine dosing protocols and augment drug safety and efficacy.

Clinical Research: Embark on an enlightening expedition through the vast landscapes of clinical research, where Verinurad-[d6] emerges as a cornerstone in assessing the therapeutic efficacy and safety profile of Verinurad in individuals grappling with gout and hyperuricemia. By scrutinizing the drug's performance in trials, researchers unearth its pharmacodynamic effects and potential adverse reactions, guiding the formulation of optimal dosing regimens and strategic treatment approaches.

Biotransformation Studies: Immerse yourself in the captivating domain of biotransformation studies, where Verinurad-[d6] takes center stage in unraveling the intricate breakdown and metabolization pathways of the drug. Leveraging this deuterated variant, researchers unveil the metabolic transformations and potential drug interactions that could significantly impact treatment outcomes, laying the foundation for the development of safer and more efficacious therapeutic strategies.

Stable Isotope Labeling: Dive deep into the fascinating world of stable isotope labeling studies with Verinurad-[d6] as your guiding light. As a deuterated compound, it serves as a critical component in mass spectrometry, serving as an internal standard for precise quantification of Verinurad levels in plasma samples. This application stands as an indispensable tool in drug development, enabling meticulous measurement and quality control in analytical assays, thereby elevating the standards of pharmaceutical research and development to new heights.