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Vernakalant-[d6] Hydrochloride

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Vernakalant-[d6] Hydrochloride

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General Information
Catalog: BLP-007596
CAS: 866455-16-5
Molecular Formula: C20H26D6ClNO4
Molecular Weight: 391.96

Chemical Structure

Description	Vernakalant-[d6] Hydrochloride is a labelled analog of Vernakalant hydrochloride. Vernakalant hydrochloride, also known as RSD1235, is a novel, relatively atrial-selective antiarrhythmic drug which can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg. It belongs a mixed ion channel blocker. It may be more atrial-selective than available agents in treatment of antiarrhythmic. It blocks atrial potassium channels, thereby prolonging repolarization. It also blocks atrial sodium channels. It also slightly blocks the hERG potassium channel, leading to a prolonged QT interval, which may theoretically increase the risk of ventricular tachycardia, though this does not seem to be clinically relevant.
Synonyms	Vernakalant bis(Methoxy-d3) Hydrochloride; (3R)-1-[(1R,2R)-2-[2-(3,4-Di(methoxy-d3)phenyl)ethoxy]cyclohexyl]-3-pyrrolidinol Hydrochloride; (1R,2R)-2-((3R)-Hydroxypyrrolidinyl)-1-(3,4-di(methoxy-d3)phenethoxy)cyclohexane Monohydrochloride; (1R,2R)-2-((3R)-Hydroxypyrrolidinyl)-1-[2-(3,4-di(methoxy-d3)phenyl)ethoxy]cyclohexane Monohydrochloride; (3R)-1-[(1R,2R)-2-[2-(3,4-Di(methoxy-d3)phenyl)ethoxy]cyclohexyl]-3-pyrrolidinol Monohydrochloride; RSD 1235-d3
Related CAS	748810-28-8 (unlabelled) 866525-69-1 (free base)

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