Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
General Information |
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Catalog: BLP-007596 |
CAS: 866455-16-5 |
Molecular Formula: C20H26D6ClNO4 |
Molecular Weight: 391.96 |
Chemical Structure |
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Description | Vernakalant-[d6] Hydrochloride is a labelled analog of Vernakalant hydrochloride. Vernakalant hydrochloride, also known as RSD1235, is a novel, relatively atrial-selective antiarrhythmic drug which can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg. It belongs a mixed ion channel blocker. It may be more atrial-selective than available agents in treatment of antiarrhythmic. It blocks atrial potassium channels, thereby prolonging repolarization. It also blocks atrial sodium channels. It also slightly blocks the hERG potassium channel, leading to a prolonged QT interval, which may theoretically increase the risk of ventricular tachycardia, though this does not seem to be clinically relevant. |
Synonyms | Vernakalant bis(Methoxy-d3) Hydrochloride; (3R)-1-[(1R,2R)-2-[2-(3,4-Di(methoxy-d3)phenyl)ethoxy]cyclohexyl]-3-pyrrolidinol Hydrochloride; (1R,2R)-2-((3R)-Hydroxypyrrolidinyl)-1-(3,4-di(methoxy-d3)phenethoxy)cyclohexane Monohydrochloride; (1R,2R)-2-((3R)-Hydroxypyrrolidinyl)-1-[2-(3,4-di(methoxy-d3)phenyl)ethoxy]cyclohexane Monohydrochloride; (3R)-1-[(1R,2R)-2-[2-(3,4-Di(methoxy-d3)phenyl)ethoxy]cyclohexyl]-3-pyrrolidinol Monohydrochloride; RSD 1235-d3 |
Related CAS | 748810-28-8 (unlabelled) 866525-69-1 (free base) |
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