Inquiry List

* Name:
* Phone:
* Service & Products of Interested: [Labelled Inhibitors] VX-561 (1413431-07-8)
Project Description:
* Quantity
* Email:
* Organization We recommend you to leave us your work email address so that we can serve you better. Please leave your organization information here if you don't have a work email address.
* Verification Code:

Our Highlights

Optimal Prices
Buying products on this site guarantees the best price
Flexible Batches
Flexible batch size to meet different needs of global customers
Prompt Delivery
Warehouses in multiple cities to ensure timely delivery
Quality Assurance
Strict process parameter control to ensure product quality
One-to-one Customization
One-to-one custom synthesis for special structural needs

Application Area

Environmental

Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.

Clinical diagnostic

In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.

Organic Chemistry

Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.

Metabolic Research

Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.

VX-561

Inquiry

General Information
Catalog: BLP-013928
CAS: 1413431-07-8
Molecular Formula: C24H19D9N2O3
Molecular Weight: 401.55

Chemical Structure

Description	VX-561, also known as d9-ivacaftor, is an agonist of cystic fibrosis transmembrane conductance regulator (CFTR) channel developed for the treatment of cystic fibrosis. VX-561 is in a phase II clinical trial for safety and efficacy evaluation.
Synonyms	CTP-656; N-(2-(tert-butyl)-5-hydroxy-4-(2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide; d9-ivacaftor
IUPAC Name	N-[2-tert-butyl-4-[1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl]-5-hydroxyphenyl]-4-oxo-1H-quinoline-3-carboxamide
Related CAS	873054-44-5 (unlabelled)
Canonical SMILES	CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
InChI	InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)/i4D3,5D3,6D3
InChI Key	PURKAOJPTOLRMP-ASMGOKTBSA-N
Melting Point	>288°C (dec.)
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly, Heated)
Appearance	White to Off-white Solid
Application	potential treatment of cystic fibrosis
Storage	Store at -20°C