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Zonisamide-[13C6]

General Information
Catalog: BLP-008194
CAS: 1435934-68-1
Molecular Formula: C2[13C]6H8N2O3S
Molecular Weight: 218.18
Chemical Structure
Zonisamide-[13C6]
Description An isotope labelled Zonisamide. Zonisamide can be used to treat the symptoms of epilepsy and Parkinson's disease.
IUPAC Name 1,2-benzoxazol-3-ylmethanesulfonamide
Related CAS 68291-97-4 (unlabelled)
Canonical SMILES C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
InChI InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)/i1+1,2+1,3+1,4+1,6+1,8+1
InChI Key UBQNRHZMVUUOMG-IXSHGPIVSA-N
Purity 95% by HPLC; 98% atom 13C

Zonisamide-[13C6], a labeled compound with diverse applications in neuroscience and pharmacology, opens avenues for innovative research and preclinical endeavors. Below, explore the key applications of Zonisamide-[13C6]:

Pharmacokinetics and Drug Metabolism Studies: Delving into the intricate realm of absorption, distribution, metabolism, and excretion (ADME) of zonisamide, Zonisamide-[13C6] emerges as a crucial tool for unraveling the mysteries of this drug’s journey in biological systems. This labeled compound facilitates precise quantification and real-time monitoring of zonisamide in diverse tissues and fluids. By mastering the pharmacokinetics of zonisamide, researchers chart pathways to optimized dosing regimens, enhancing drug efficacy and safety profiles with precision.

Neuropharmacology Research: At the forefront of neuroscientific inquiry, Zonisamide-[13C6] serves as an invaluable ally in dissecting the pharmacodynamics of zonisamide within the central nervous system. Researchers leverage this labeled compound to decode the intricate mechanisms of zonisamide’s action, including its impact on neurotransmitter levels and neural activities. These insights pave the way for novel therapeutic strategies in combating neurological disorders like epilepsy and Parkinson’s disease with enhanced efficacy and precision.

Quantitative Mass Spectrometry: In the realm of analytical chemistry, Zonisamide-[13C6] shines as an indispensable internal standard for conducting quantitative mass spectrometric assays with unwavering accuracy and reproducibility. Its application ensures consistent and reliable measurement of zonisamide concentrations in various biological samples, underpinning clinical diagnostics and pharmaceutical research endeavors. This precision is instrumental in enabling meticulous drug monitoring and efficient therapeutic drug management strategies.

Toxicology Studies: Stepping into the realm of toxicological exploration, Zonisamide-[13C6] emerges as a key player in unraveling the safety profile and potential adverse effects of zonisamide. Through careful tracing of the labeled drug within animal models, researchers navigate the complex terrain of toxicokinetics, shedding light on potentially harmful metabolites. These essential studies safeguard the use of zonisamide in clinical settings, ensuring compliance with regulatory standards and enhancing patient safety through meticulous evaluation.

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