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Labelled Nucleic Acids

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BOC Sciences is committed to providing customers with the broadest variety of isotope-labeled nucleic acid-related products. The isotope-labeled nucleic acid-related products we provide include internal isotopic standards for purine, pyrimidine, inosine, uridine, adenosine, cytidine, thymidine, and guanosine derivatives.

What are Nucleic Acids?

Nucleosides consist of a pentose sugar (ribose or deoxyribose) and a nitrogenous base (pyrimidine or purine) linked by a glycosidic bond. Nucleosides can be categorized into ribonucleosides and deoxyribonucleosides by their pentose sugars. According to the different nitrogenous bases, nucleosides could be divided into adenosine, thymidine, uridine, guanosine, cytidine, inosine, etc. Nucleosides and phosphates synthesize nucleotides, and four unique nucleotides form the basis of nucleic acids.

Nucleic acids are macromolecular compounds polymerized by monomeric nucleotides and are functional molecules with large molecular weights, including DNA and RNA. Their main functions are include storage, transmission, and performance of genetic information and are the protagonist of modern molecular biology. Nucleic acids are widely used to support the development of medicine, food, cosmetics, agriculture, etc.

  • In medicine: Nucleic acid drugs are a novel class of biopharmaceuticals, which have broad prospects in anti-cancer, anti-virus, treatment of cerebrovascular diseases, prevention of hypertension, and treatment of anemia.
  • In food: Nucleic acid derivatives can be used as umami agents.
  • In cosmetics: Nucleic acid has the effect of promoting protein synthesis and upregulating skin metabolism.
  • In agriculture: Nucleic acid derivatives could be used as prevention for plant diseases and insect pests.

What are Isotope-labeled Nucleic Acids?

Frequently used nucleosides (such as uridine, thymidine, etc.) can be used for nucleic acid labeling, as well as chromosomal in situ hybridization or electron microscopy nucleic acid analysis. Stable isotopes are used in complex environments to trace the DNA/RNA of microorganisms and study metabolic functions, which significantly strengthen scientific research development and application value.

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